Progress of Autophagy in Epilepsy Research

Epilepsy is a clinical syndrome caused by highly synchronized abnormal discharges of neurons in the brain. It common disease nervous system. The pathogenesis epilepsy has not been fully understood yet. main pathological changes after seizures are programmed neuronal death and glial proliferation. Autophagy catabolic process. Moderate autophagy critical to maintain homeostasis cell health, while can lead disease. A number studies have proved that mechanism epilepsy, there also literatures induced endoplasmic reticulum stress reduce damage triggered thus playing protective role neurons. This article reviews relationship between order provide basis for further study pathway pathophysiology epilepsy.